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Polyphosphate: The Actual Biology of an Ancient Polymer

Tentative Programme 2023 (v.24/04/2023)

Edificio Constitución 1812

May 9, 2023.

(14:00) Registration Open.

(16:00-16:10) Introductory Welcome: Felix A. Ruiz (Universidad de Cádiz, Chair).

(16:10-17:00) Plenary Lecture: James Morrissey (University of Michigan): How and why an ancient polymer end up modulating haemostasis, thrombosis, and inflammation.

(17:00-17:30) Coffee Break (Networking activity: Speed dating, Connecting young and consolidated polyP scientists).

(17:30-18:00) Adolfo Saiardi (LMCB, University College London): Inorganic polyphosphate in mammalian cells: where the bulk is and what it might be doing there.

(18:00-18:30) Selected presentation: Andreas Mayer (Université de Lausanne): The multilayered approach of yeast to intracellular Pi homeostasis - The INPHORS pathway.

(18:30-19:00) Selected presentation: Mayara Bertolini (University of Georgia): Vacuolar Transporter Chaperone 4 (TcVtc4) is essential for the infective stages of Trypanosoma cruzi.

(19:30) Welcome Dinner: “Parador de Cádiz


May 10, 2023.

Morning Section: Mammalian polyphosphate.

Chair: Adolfo Saiardi (LMCB, University College London).

(9:00-9:30) Ursula Jakob (University of Michigan): Chaperoning property of polyphosphate.

(9:30-10:00) IUBMB Lecture: Maria E. Solesio (Rutgers University): Inorganic polyphosphate: a key regulator of mitochondrial physiology.

(10:00-10:30) Selected presentation: Vernon Anderson (Children's Hospital of Philadelphia): Availability of mitochondrial disease models for investigating the role of polyphosphate in bioenergetics.

(10:30-11:00) Coffee break.

(11:00-11:30) Rashna Bhandari (Centre for DNA Fingerprinting and Diagnostics. India): The ring rules the chain - regulation of mammalian polyP by InsP7.

(11:30-12:00) Selected presentation: Filip Kuś (Medical University of Gdansk): Unresolved role of Inorganic polyphosphate in tumor progression and metastasis.

(12:00-12:30) Selected presentation: Magdalena Sroka (Intercollegiate Faculty of Biotechnology UG&MUG): The activity of long isoform of E.coli CobB deacetylase is modulated by PolyP.

(13.00-14.00) Lunch.

(14.00-14.30) Putting up of Posters.

Afternoon Section: PolyP in microorganisms I.

Chair: Josep Clotet (Universitat Internacional de Catalunya).

(14:30-15:00) Alison Baker (University of Leeds): Overexpression of PSR1 in Chlamydomonas reinhardtii induces luxury Phosphorus uptake.

(15:00-15:30) Emanuel Sanz Luque (Universidad de Córdoba): Polyphosphate role in the acclimation of microalgae to nutrient deprivation.

(15.30 – 17.00) Poster Session I: (ACCEPTED POSTERS) / Coffee Break.

(17:00-17:30) Ursula Fleig (Heinrich-Heine-Universität): Regulation of polyP generation and its role in fission yeast mitosis.

(17:30-18:00) Selected presentation: Liam McCarthy (University of Ottawa): Ddp1 cooperates with Ppx1 to counter a stress response initiated by nonvacuolar polyphosphate.

Social event:

(18:30) Guided walking tour around the city of Cádiz (in collaboration with the City Hall “Ayuntamiento de Cádiz”). Start: Meeting venue / Finish: Plaza San Juan de Dios.  

(20:00) Flamenco show and tapas (Taberna El Marqués de Cádiz).


May 11, 2023.

Section: Polyphosphate, Platelets, and Coagulation.

Chair: Rashna Bhandari (Centre for DNA Fingerprinting and Diagnostics. India).

(9:00-9:30) Felix A. Ruiz (Universidad de Cádiz): Polyphosphate in Blood Plasma in Health and Disease.

(9:30-10:00) Brigitte van Zundert (Universidad Andrés Bello, Chile): Excessive release of polyP by ALS astrocytes is toxic to motoneurons.

(10:00 -10:30) Thomas Renné (Universitätsklinikum Hamburg): Activities and regulation of the polyphosphate/contact system-axis in thrombo-inflammation.

(10:30-11:00) Coffee break.

Section: PolyP in microorganisms II.

(11:00-11:30) Selected presentation: Lisa Racki (The Scripps Research Institute): Polyphosphate condensates as drivers and passengers in chromatin dynamics in the bacterial pathogen Pseudomonas aeruginosa.

(11:30 -12:00) Selected presentation: Tatiana Zúñiga Burgos (University of Leeds): When Less may be More: Starvation and Phosphorus overplus in Chlamydomonas reinhardtii.

(12:00 -12:30) Selected presentation: Antonio Llop (Universidad de Alicante): Overexpression of the Pyridoxal phosphate-binding protein PipY induces accumulation of giant polyphosphates granules in the cyanobacterium Synechococcus elongatus PCC7942.

(13.00 – 14.00) Lunch.

Afternoon Section: New trends in polyP.

Chair: Dieter Jendrossek (Universität Stuttgart).

(14.00 – 16.00) Poster Session II (ACCEPTED POSTERS).

(16:00-16:30) Javier Jiménez (Universitat Internacional de Catalunya): Insights into nuclear polyP in human cells.

(16:30-17:00) Evgeny Pavlov (NYU College of Dentistry): Polyphosphate and ion channels.

(17:00-17:30) Coffee Break.

(17:30-18:00) Henning J. Jessen (Albert-Ludwigs-Universität Freiburg): Ultraphosphate chemistry.

(18:00-18:30) Selected presentation: Alexander Deitert (RWTH Aachen University): Contributing to a circular phosphate economy Polyphosphate production in Saccharomyces cerevisiae.

(18:30-19:00) Selected presentation: Xingyu Yang (Hong Kong University of Science and Technology): The Challenges in Quantifying PolyP in Natural Water Samples.

(20:00) Social Dinner “Baluarte de los Mártires


May 12, 2023.

(10:00-12:00) Closing Meeting: Building the future in polyP community (Career progression advice).

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